|(2E,4E)-5-(苯并[d][1,3]二氧杂戊环-5-基)-1-(哌啶-1-基)戊烷-2,4-二烯-1-酮|CsnPharm

CAS No.: 94-62-2

胡椒碱 Catalog No. CSN12413

Synonyms: 胡椒碱;Bioperine;1-Piperoylpiperidine

Piperine is a major alkaloid isolated from the P. longum fruits which possesses anti-inflammatory and antiarthritic effects.

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实验方案

技术信息

生物活性

描述Piperine is a natural alkaloid isolated from pepper and inhibits the activity of P-glycoprotein and CYP3A4 with IC₅₀[3]. In vivo, at the dose of 3.5 mg/kg, the bioavailability of Piperine was calculated to be 25.36% and its AUC0→t was unproportionally increased with doses^[4]. Moreover, piperine effectively reduced the aureus-induced overexpression of TNF-α, IL-1β, and IL-6 but increased the expression of IL-10. The phosphorylation of I-κB, p65, p38, ERK, and JNK was inhibited by piperine in a dose-dependent manner^[5]. Piperine has been found to have immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01640197	Healthy	Phase 1	Completed	-	United Kingdom ... more >> Brain performance and nutrition research centre, Northumbria university Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 8ST Collapse <<
NCT00065741	HIV Seronegativity	Phase 1	Completed	-	United States, North Carolina ... more >> General Clinical Research Center, Univiversity Of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27599 Collapse <<
NCT01640197	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5046 mL
- 17.5230 mL
- 35.0459 mL
- 5 mM
- 0.7009 mL
- 3.5046 mL
- 7.0092 mL
- 10 mM
- 0.3505 mL
- 1.7523 mL
- 3.5046 mL

技术信息

CAS号

94-62-2

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H15NO5

运输

蓝冰

分子量

285.34

别名

胡椒碱;Bioperine;1-Piperoylpiperidine

溶解度

DMSO	57.0 mg/mL (199.8 mM)
Water	Insoluble
Ethanol	57.0 mg/mL (199.8 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01640197	Healthy	Phase 1	Completed	-	United Kingdom ... more >> Brain performance and nutrition research centre, Northumbria university Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 8ST Collapse <<
NCT00065741	HIV Seronegativity	Phase 1	Completed	-	United States, North Carolina ... more >> General Clinical Research Center, Univiversity Of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27599 Collapse <<
NCT01640197	-	-	Completed	-	-
NCT01288859	Healthy	Not Applicable	Completed	-	Italy ... more >> Department of Food Science Portici, Italy, 80055 Collapse <<
NCT03201835	Healthy Volunteers	Phase 1	Completed	-	Israel ... more >> Clinical Research Center (CRC)- Souraskey Medical center Tel Aviv, Israel Collapse <<
NCT03206567	Hair Thinning	Not Applicable	Recruiting	December 2017	United States, California ... more >> Ablon Skin Institute & Research Center Recruiting Manhattan Beach, California, United States, 90266 Contact: Shelley Joyce, RN, BSN, CRC 310-727-3376 shelley@abloninstitute.comm Principal Investigator: Glynis Ablon, MD, FAAD Collapse <<
NCT01729143	Obesity	Not Applicable	Completed	-	United States, North Carolina ... more >> UNC Chapel Hill Nutrition Research Institute Kannapolis, North Carolina, United States, 28081 Collapse <<
NCT01288859	-	-	Completed	-	-
NCT00181662	Healthy	Not Applicable	Completed	-	United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse <<
NCT03475017	Chronic Kidney Diseases	Phase 3	Enrolling by invitation	December 30, 2021	Brazil ... more >> Denise Mafra Niterói, Rio De Janeiro, Brazil Collapse <<
NCT03621865	Healthy	Not Applicable	Completed	-	France ... more >> Biofortis Mérieux NutriSciences Saint-Herblain, France, 44800 Collapse <<
NCT02542449	Obesity	Phase 4	Completed	-	Italy ... more >> IRCCS Istituto Auxologico Italiano Milano, Italy, 20145 Collapse <<
NCT01331382	Healthy	Not Applicable	Completed	-	United Kingdom ... more >> Brain performance and nutrition research centre, Northumbria university Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 8ST Collapse <<
NCT01324089	Focus of the Study: Normal Vol... more >>unteers Collapse <<	Not Applicable	Completed	-	United States, Wisconsin ... more >> University of Wisconsin Madison, Wisconsin, United States, 53792 Collapse <<
NCT01893424	Pain	Phase 1	Completed	-	Israel ... more >> Hadassah medical organization Jerusalem, Israel Collapse <<
NCT02598726	Bladder Spasm ... more >> Malignant Neoplasm Pain Urinary Urgency Collapse <<	Phase 1	Recruiting	March 15, 2021	United States, Minnesota ... more >> Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Clinical Trials Referral Office 855-776-0015 Principal Investigator: Aminah Jatoi Collapse <<
NCT00799630	Nutrition Processes	Not Applicable	Completed	-	France ... more >> Service de Physiologie Clinique et de l'Exercice, CHU Saint-Etienne Saint-Etienne, France, 42055 Collapse <<
NCT01383694	Deglutition Disorders	Phase 1 Phase 2	Completed	-	Spain ... more >> Hospital de Mataró Mataró, Barcelona, Spain, 08304 Collapse <<

胡椒碱 Catalog No. CSN12413

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